"How reliable is the 2010 Mercedes-Benz E350?"

"Based on 228 NHTSA complaints, the 2010 Mercedes-Benz E350 has a median complaint mileage of 59956 miles. The most common issue is Air Bags."

"What are common problems with the 2010 Mercedes-Benz E350?"

"The most frequently reported component in NHTSA complaints for the 2010 Mercedes-Benz E350 is Air Bags, accounting for a significant portion of the 228 total complaints filed."

2010 Mercedes-Benz E350: Reliability Data

Source: NHTSA — 228 complaints

228

Total Complaints

59,956mi

Median Mileage

Air Bags

Top Issue

Crash Reports

When Do Complaints Happen?

Distribution of NHTSA complaints by vehicle mileage at time of report.

24,000 25th Percentile

59,956 Median Mileage

94,000 75th Percentile

What Fails?

Most reported component issues from NHTSA complaints.

Air Bags

Unknown Or Other

Fuel/Propulsion System

Engine

Suspension

Electrical System

Power Train

Service Brakes

Body

Steering

Severity Assessment

Crashes

Fires

Injuries

Deaths

Sample Complaint Reports

"TL*THE CONTACT OWNS A 2010 MERCEDES BENZ 350E. HE STATED THAT ON THE LEFT SIDE OF THE STEERING COLUMN THERE ARE 2 OPTIONS, ONE FOR THE CRUISE CONTROL AND ONE FOR THE TURN SIGNAL; HOWEVER, WHEN ATTEMPTING TO ACTIVATE THE TURN SIGNALS, THE CRUISE CONTROL ACTIVATED. THE TURN SIGNAL AND THE CRUISE CONTR..."

"THIS COMPLAINT IS FOR A 2010 BMW 535I XDRIVE. I WENT INTO THE GARAGE TO START MY CAR THIS MORNING WEDNESDAY, 10/28/09 AND THE CHECK ENGINE LIGHT CAME ON AND THE CAR STARTED SHAKING. I MOVED THE CAR OUT OF THE GARAGE AND SHUT OFF THE ENGINE TO SEE IF IT WOULD RESET, I STARTED THE CAR UP AGAIN AND T..."

"THE TURN SIGNAL LEVER AND CRUISE CONTROL LEVER ARE TOO CLOSE TOGETHER AND DANGEROUS. ACTIVATED CRUISE CONTROL TOO MANY TIMES IN ERROR. NOT GOOD ENGINEERING. TO CORRECT IT THEY CAN TAKE OUT THE CURRENT CRUISE LEVER AND PUT IN A SHOT STUBBY ONE OR EXTEND THE TURN SIGNAL LEVER WHICH WOULD BE HARDER AS ..."

Source: NHTSA ODI Complaints Database. Names and identifying details omitted.

When Were Complaints Filed?

Number of complaints by the year the issue occurred.

When Does Each Component Fail?

Median mileage at complaint for top components.

Air Bags 68 complaints

25th: 36,387 mi Median: 54,978 mi 75th: 72,250 mi

Unknown Or Other 19 complaints

25th: 33,950 mi Median: 55,000 mi 75th: 69,750 mi

Fuel/Propulsion System 18 complaints

25th: 45,925 mi Median: 80,000 mi 75th: 83,862 mi

Engine 15 complaints

25th: 49,663 mi Median: 59,947 mi 75th: 95,500 mi

Suspension 15 complaints

25th: 19,000 mi Median: 65,500 mi 75th: 116,000 mi

Where Are Complaints Coming From?

Top states by complaint count.

CA: 40 NJ: 28 FL: 28 NY: 18 VA: 11 TX: 9 OH: 8 MD: 7 WA: 7 TN: 7

Who Files Complaints?

0.9%

Original Owners

99.1%

Second+ Owners

Mercedes-Benz E350 — Other Years

See how this model compares across different model years.

Year	Complaints	Median Mileage	Top Issue	Crashes
2006	481	90,000	Fuel/Propulsion System	20
2007	397	80,000	Fuel/Propulsion System	1
2008	219	86,500	Fuel/Propulsion System	13
2009	76	66,500	Fuel/Propulsion System	4
2011	263	55,539	Air Bags	14
2012	253	66,400	Air Bags	8
2013	214	46,788	Air Bags	29
2014	363	41,000	Air Bags	20
2015	39	25,000	Electrical System	4
2016	72	39,000	Electrical System	9

Data source: View this vehicle on NHTSA.gov | NHTSA ODI Complaints Database. Public domain.

Methodology: Complaint counts and mileage distributions are computed directly from consumer-reported NHTSA complaints. This data represents reported issues, not failure rates — vehicles without complaints are not represented. Full methodology.

Data through: 2026-03-28