"How reliable is the 2006 Mercedes-Benz E350?"

"Based on 481 NHTSA complaints, the 2006 Mercedes-Benz E350 has a median complaint mileage of 90000 miles. The most common issue is Fuel/Propulsion System."

"What are common problems with the 2006 Mercedes-Benz E350?"

"The most frequently reported component in NHTSA complaints for the 2006 Mercedes-Benz E350 is Fuel/Propulsion System, accounting for a significant portion of the 481 total complaints filed."

2006 Mercedes-Benz E350: Reliability Data

Source: NHTSA — 481 complaints

481

Total Complaints

90,000mi

Median Mileage

Fuel/Propulsion System

Top Issue

Crash Reports

When Do Complaints Happen?

Distribution of NHTSA complaints by vehicle mileage at time of report.

62,250 25th Percentile

90,000 Median Mileage

120,150 75th Percentile

What Fails?

Most reported component issues from NHTSA complaints.

Fuel/Propulsion System

143

Fuel System, Gasoline

Engine

Service Brakes

Power Train

Electrical System

Engine And Engine Cooling

Air Bags

Unknown Or Other

Automatic Transmission

Severity Assessment

Crashes

Fires

Injuries

Deaths

Sample Complaint Reports

"MERCEDES BENZ E350 TIRE EQUIPMENT BURST WHILE DRIVING.***NO ANSWER REQUIRED***. *MR THE CONSUMER REQUEST REIMBURSEMENT FOR THE COST OF THE NEW TIRE INSTALLED ON THE VEHICLE. *NM"

"TRANSMISSION FAILED ON 07-26-2005 LEFT ME STRANDED ON STREET IN HILLSIDE NJ CAR HAD TO BE TOWED TO DEALERSHIP. THEY INDICATED IT WAS A COMPUTER PROBLEM MALFUNCTION AND REPLACED COMPUTER. TRANSMISSION STILL HAVING SLIPPING OCCASIONALLY SVC DEPT SAID THEY FIND NOTHING WRONG. MB IGNORING MY REQUEST ..."

"I PURCHASED A 2006 MERCEDES E350 IN AUGUST 13 AND TODAY WITH 1175 MILES ON THE ODOMETER; THE TRANSMISSION FAILED. I WAS DRIVING ABOUT 30 MPH AND ALL OF A SUDDEN; THE ENGINE HIGH REVVED LIKE IT WENT INTO NEUTRAL. THE VEHICLE WAS STUTTERING LIKE THE CLUTCH WAS SLIPPING (THE CAR IS A AUTOMATIC) AND WA..."

Source: NHTSA ODI Complaints Database. Names and identifying details omitted.

When Were Complaints Filed?

Number of complaints by the year the issue occurred.

When Does Each Component Fail?

Median mileage at complaint for top components.

Fuel/Propulsion System 143 complaints

25th: 64,746 mi Median: 95,750 mi 75th: 120,000 mi

Fuel System, Gasoline 75 complaints

25th: 64,075 mi Median: 84,011 mi 75th: 100,760 mi

Engine 50 complaints

25th: 91,250 mi Median: 111,000 mi 75th: 140,675 mi

Service Brakes 46 complaints

25th: 108,616 mi Median: 131,000 mi 75th: 147,000 mi

Power Train 29 complaints

25th: 66,323 mi Median: 86,000 mi 75th: 119,250 mi

Where Are Complaints Coming From?

Top states by complaint count.

CA: 115 FL: 60 TX: 56 AZ: 24 VA: 20 OH: 17 GA: 17 NC: 15 MA: 14 NJ: 12

Who Files Complaints?

2.7%

Original Owners

97.3%

Second+ Owners

Mercedes-Benz E350 — Other Years

See how this model compares across different model years.

Year	Complaints	Median Mileage	Top Issue	Crashes
2007	397	80,000	Fuel/Propulsion System	1
2008	219	86,500	Fuel/Propulsion System	13
2009	76	66,500	Fuel/Propulsion System	4
2010	228	59,956	Air Bags	17
2011	263	55,539	Air Bags	14
2012	253	66,400	Air Bags	8
2013	214	46,788	Air Bags	29
2014	363	41,000	Air Bags	20
2015	39	25,000	Electrical System	4
2016	72	39,000	Electrical System	9

Data source: View this vehicle on NHTSA.gov | NHTSA ODI Complaints Database. Public domain.

Methodology: Complaint counts and mileage distributions are computed directly from consumer-reported NHTSA complaints. This data represents reported issues, not failure rates — vehicles without complaints are not represented. Full methodology.

Data through: 2026-03-28