"How reliable is the 2006 Mercedes Benz C350?"

"Based on 24 NHTSA complaints, the 2006 Mercedes Benz C350 has a median complaint mileage of 71000 miles. The most common issue is FUEL/PROPULSION SYSTEM."

"What are common problems with the 2006 Mercedes Benz C350?"

"The most frequently reported component in NHTSA complaints for the 2006 Mercedes Benz C350 is FUEL/PROPULSION SYSTEM, accounting for a significant portion of the 24 total complaints filed."

2006 Mercedes Benz C350: Reliability Data

Source: NHTSA — 24 complaints

Total Complaints

71,000mi

Median Mileage

FUEL/PROPULSION SYSTEM

Top Issue

Crash Reports

When Do Complaints Happen?

Distribution of NHTSA complaints by vehicle mileage at time of report.

49,654 25th Percentile

71,000 Median Mileage

98,000 75th Percentile

What Fails?

Most reported component issues from NHTSA complaints.

FUEL/PROPULSION SYSTEM

ENGINE

AIR BAGS

FUEL SYSTEM, GASOLINE

STRUCTURE

SUSPENSION

ELECTRICAL SYSTEM

SERVICE BRAKES

POWER TRAIN

FUEL SYSTEM, GASOLINE:DELIVERY

Severity Assessment

Crashes

Fires

Injuries

Deaths

Sample Complaint Reports

"MY MERCEDES E350 REPORTED ENGINE ERROR CODES P0016 AND P0017. DETAILED ERROR CODE READING. P0016 CRANKSHAFT POSITION CAMSHAFT POSITION CORRELATION BANK 1 SENSOR A P0017 CRANKSHAFT POSITION CAMSHAFT POSITION CORRELATION BANK 1 SENSOR B I HAVE 70,000 MILES ON THE CAR NOW AND HAVE FOUND OUT THAT..."

"THE FITING ARE NOT MADE WELL ,AND OIL IS DISTRIBUTE ON EVERY PART OF THE FRONT ENGINE AND TRANSMISSION AREA CAUSING SMOKE AND CAN CAUSE FIRE. IF IT COME APART. *TR"

"UPON FILLING GAS TANK NOTICED FUEL SMELL IN GARAGE. THIS HAPPENED MANY TIMES. DECIDED NOT TO FILL COMPLETELY, AND SMELL WENT AWAY. I NOW ONLY PUT 10 GALLONS IN THE TANK AND DO NOT FILL UP. I'M SENDING THIS BECAUSE I SAW AN ARTICLE IN THE LA TIMES INDICATING THIS MAY BE PROBLEM WITH "E" CLASS VEHI..."

Source: NHTSA ODI Complaints Database. Names and identifying details omitted.

Data source: View this vehicle on NHTSA.gov | NHTSA ODI Complaints Database. Public domain.

Methodology: Complaint counts and mileage distributions are computed directly from consumer-reported NHTSA complaints. This data represents reported issues, not failure rates — vehicles without complaints are not represented. Full methodology.

Data through: 2026-03-28