How Long Does Humulin R U-500 Last?

16.2 Storage and Handling Dispense in the original sealed carton with the enclosed Instructions for Use. Protect from heat and light. Do not freeze. Do not use if it has been frozen. Do not shake the vial. See Table 2 below for storage conditions. Table 2: Storage Conditions for HUMULIN R U-500 Vials and Pens a When stored at room temperature, HUMULIN R U-500 vial can only be used for a total of 40 days, including both not in-use (unopened) and in-use (opened) storage time. b When stored at room temperature, HUMULIN R U-500 KwikPen can only be used for a total of 28 days, including both not in-use (unopened) and in-use (opened) storage time. Not In-use (Unopened) In-use (Opened) Room Temperature (up to 86°F [30°C]) Refrigerated (36° to 46°F [2° to 8°C]) Room Temperature (up to 86°F [30°C]) Refrigerated (36° to 46°F [2° to 8°C]) 20 mL multiple-dose vial a 40 days Until expiration date 40 days 40 days 3 mL single-patient-use HUMULIN R U-500 KwikPen b 28 days Until expiration date 28 days Do not refrigerate.